Behavioral and Integrative Treatment Development Program (R01 Clinical Trial Optional) | PAR 19 212

Opportunity Information: Apply for PAR 19 212

The Behavioral and Integrative Treatment Development Program (R01 Clinical Trial Optional) is a National Institutes of Health (NIH) grant opportunity (Funding Opportunity Number PAR 19 212) designed to move behavioral intervention research in substance use and addiction treatment forward, particularly research that is ready to rigorously test whether an intervention works and how to make it work better in real-world care. The core emphasis is on developing and evaluating behavioral treatments and integrated approaches that combine behavioral and pharmacological strategies, with a strong interest in studies that can demonstrate efficacy, clarify how and why behavior change happens, and refine interventions so they are more effective, scalable, and sustainable. The mechanism is an R01 research project grant, and the announcement is "clinical trial optional," meaning applicants may propose either clinical trials or other appropriate efficacy-focused research designs, depending on the specific aims.

The FOA centers on behavioral intervention development research that tackles several practical and scientifically important questions. It encourages projects that test efficacy through well-controlled studies, including Stage II and Stage III efficacy research, which typically involves more advanced testing of interventions that have already shown promise and now need stronger evidence across settings, populations, or delivery formats. Beyond basic efficacy, NIH is looking for studies that investigate mechanisms of behavior change (what components drive outcomes and through what pathways), dose-response relationships (how much intervention is needed, how intensity or frequency affects outcomes), treatment optimization (systematically improving intervention components for best effect), and sequencing strategies (determining the best order or combination of behavioral and medication-based treatments, including combined, sequential, or fully integrated models).

In terms of what topics and populations are in scope, the program is aimed squarely at drug abuse treatment interventions, including work focused on people with co-occurring conditions or comorbidities, which is often where treatment gets complicated and outcomes are hardest won. It also explicitly supports treatment and adherence interventions, recognizing that even highly effective treatments fail when patients cannot or do not stay engaged. A notable emphasis is placed on using technology to strengthen interventions and improve implementability and sustainability. That could include digital tools, telehealth delivery, mobile supports, remote monitoring, or other technology-enabled approaches that help interventions reach more people, reduce burden on clinics, and maintain effects over time.

The FOA also prioritizes research at the intersection of substance use treatment and HIV prevention and care. This includes interventions intended to prevent the acquisition or transmission of HIV among individuals receiving drug abuse treatment, as well as interventions that promote adherence to drug abuse treatment itself and to HIV and addiction medications. Another clearly stated area is interventions addressing substance misuse alongside chronic pain, reflecting the overlapping clinical challenges of pain management, opioid and other substance misuse risks, and long-term functioning.

Eligibility is broad, which is typical for NIH opportunities, and is structured to invite proposals from a wide range of organizations that can carry out rigorous research. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); tribal organizations (including those other than federally recognized tribal governments); public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education where relevant); for-profit organizations (other than small businesses); and small businesses. The FOA also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations), which signals interest in diverse settings and broader generalizability when appropriate.

Administratively, this is a discretionary grant under NIH, with activity categories in education and health and CFDA numbers 93.273 and 93.279. The source data lists an award ceiling of 225,000 (as provided in the record) and indicates the opportunity was created on 2019-03-07, with an original closing date of 2022-03-23. Overall, the program is best understood as supporting advanced behavioral and integrated treatment development work that is ready for strong efficacy testing and optimization, especially where adherence, comorbidity, technology-enabled delivery, HIV-related outcomes, and chronic pain intersect with substance use treatment.

• The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Behavioral and Integrative Treatment Development Program (R01 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273, 93.279.
• This funding opportunity was created on 2019-03-07.
• Applicants must submit their applications by 2022-03-23. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $225,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 19 212

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