Opportunity Information: Apply for RFA HL 18 004
The Integrated Approaches to HIV-Related Heart, Lung, Blood, and Sleep (HLBS) Comorbidities (R01) funding opportunity (RFA-HL-18-004) is a National Institutes of Health (NIH) research grant announcement from the Department of Health and Human Services that supports hypothesis-driven, full-scale research projects using the R01 mechanism. The focus is on understanding why and how people living with HIV develop serious non-AIDS comorbidities affecting the heart, lungs, and blood system, as well as sleep disorders. Rather than studying these conditions in isolation, the FOA emphasizes integrated, systems biology style research that can connect molecular and cellular changes to clinical outcomes, with the bigger aim of clarifying disease progression pathways and pointing toward strategies that could prevent or delay these complications in HIV-infected populations.
A central requirement of the scientific approach is the use of clinical samples from HIV-infected patients. In practice, this points applicants toward studies that leverage patient-derived biospecimens (for example, blood, plasma/serum, immune cells, tissue samples when available, or other clinically collected materials) and pair them with robust clinical phenotyping of HLBS outcomes. The term "systems biology" signals an expectation for multi-layered biological measurement and integrative analysis, such as combining genomics, transcriptomics, epigenomics, proteomics, metabolomics, immune profiling, or microbiome-related data (as appropriate) with computational modeling to identify networks and perturbations associated with HLBS comorbidities in HIV. The intent is to move beyond single biomarkers and instead map out interconnected pathways that may explain increased risk, earlier onset, or accelerated progression of HLBS diseases and sleep disorders among people living with HIV, including those receiving antiretroviral therapy.
The ultimate goal described in the announcement is translational in the sense that it seeks mechanistic insight that can reveal actionable biology. By identifying the biological perturbations linked to HLBS comorbidities, the research is expected to help uncover new therapeutic targets or intervention points, ideally ones that can be used to pre-empt disease onset rather than only treating established disease. In other words, the FOA is aimed at understanding what changes in biology occur in HIV that set the stage for cardiovascular disease, pulmonary complications, hematologic abnormalities, and sleep-related disorders, and then using that understanding to inform future preventative or early-intervention strategies.
From an administrative standpoint, this is a discretionary grant opportunity under the NIH umbrella with a health-related activity category. The FOA was created on November 23, 2016, with an original closing date of December 15, 2017. The anticipated scale of support included an award ceiling of $499,999, with an expectation of about 6 awards. The announcement is associated with multiple CFDA numbers (93.233, 93.837, 93.838, 93.839, 93.840), reflecting that the topic sits at the intersection of HIV and multiple NIH mission areas connected to heart, lung, blood, and sleep research.
Eligibility is broad and includes many types of organizations that commonly apply to NIH opportunities. Eligible applicants listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other entities as described in the FOA’s additional eligibility language. This wide eligibility suggests NIH was seeking to attract multidisciplinary teams spanning academic medical centers, research institutes, public health and government-affiliated entities, and potentially industry or other research-capable organizations with access to appropriate HIV clinical cohorts and biospecimen resources.
In short, this R01 opportunity funds integrated, patient-sample-based systems biology research designed to explain the biological mechanisms that link HIV infection to higher rates and different trajectories of heart, lung, blood, and sleep comorbidities, with an emphasis on generating knowledge that can ultimately guide the identification of preventative therapeutic targets for people living with HIV.Apply for RFA HL 18 004
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Integrated Approaches to HIV-Related Heart, Lung, Blood, and Sleep (HLBS) Comorbidities (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840.
- This funding opportunity was created on Nov 23, 2016.
- Applicants must submit their applications by Dec 15, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $499,999.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
FAQs: Integrated Approaches to HIV-Related Heart, Lung, Blood, and Sleep (HLBS) Comorbidities (R01) - RFA-HL-18-004
What is this funding opportunity?
This is a National Institutes of Health (NIH) research grant opportunity from the U.S. Department of Health and Human Services titled "Integrated Approaches to HIV-Related Heart, Lung, Blood, and Sleep (HLBS) Comorbidities (R01)" (RFA-HL-18-004). It supports hypothesis-driven, full-scale research projects using the NIH R01 grant mechanism.
What is the main scientific focus of the FOA?
The FOA focuses on understanding why and how people living with HIV develop serious non-AIDS comorbidities involving the heart, lungs, blood system, and sleep disorders. The intent is to explain biological mechanisms that link HIV infection to increased risk, earlier onset, or faster progression of these conditions.
Which disease areas are included under "HLBS comorbidities" in this announcement?
HLBS refers to comorbidities affecting the heart, lungs, and blood system, as well as sleep-related disorders, specifically in the context of people living with HIV.
Does the FOA prioritize studying these conditions separately or together?
The FOA emphasizes integrated approaches rather than studying these conditions in isolation. It encourages research that connects molecular and cellular changes to clinical outcomes across HLBS and sleep comorbidities in HIV.
What kind of research approach is NIH looking for?
The FOA calls for integrated, systems biology-style research that can link multi-level biological data (molecular and cellular changes) with clinical outcomes. The goal is to clarify disease progression pathways and point toward strategies to prevent or delay these complications in HIV-infected populations.
What does "systems biology" mean in the context of this FOA?
In this announcement, "systems biology" signals an expectation for multi-layered biological measurement and integrative analysis. Examples mentioned include combining genomics, transcriptomics, epigenomics, proteomics, metabolomics, immune profiling, and/or microbiome-related data (as appropriate) with computational modeling to identify networks and biological perturbations associated with HLBS comorbidities in HIV.
Is the use of clinical samples required?
Yes. A central requirement is the use of clinical samples from HIV-infected patients. The FOA points applicants toward studies that leverage patient-derived biospecimens paired with robust clinical phenotyping of HLBS outcomes.
What types of biospecimens does the FOA reference?
Examples listed include blood, plasma/serum, immune cells, tissue samples (when available), and other clinically collected materials from HIV-infected patients.
Is strong clinical characterization expected in addition to lab measurements?
Yes. The FOA emphasizes pairing patient-derived biospecimens with robust clinical phenotyping of HLBS outcomes, connecting biological measurements to real-world clinical outcomes.
Is the FOA interested in single-biomarker studies?
The intent is to move beyond single biomarkers. The FOA encourages mapping interconnected pathways and networks that could explain HLBS comorbidities and sleep disorders among people living with HIV.
Does this opportunity include research on people receiving antiretroviral therapy (ART)?
Yes. The FOA explicitly notes interest in understanding comorbidities in people living with HIV, including those receiving antiretroviral therapy.
What is the translational goal described in the FOA?
The FOA seeks mechanistic insights that reveal actionable biology. By identifying biological perturbations linked to HLBS comorbidities, the research is expected to help uncover new therapeutic targets or intervention points, ideally aimed at preventing or delaying disease onset rather than only treating established disease.
What grant mechanism is used?
The FOA uses the NIH R01 mechanism, intended for hypothesis-driven, full-scale research projects.
Which federal agency and department are associated with this announcement?
The announcement is under the National Institutes of Health (NIH), within the U.S. Department of Health and Human Services.
What type of grant is this from an administrative standpoint?
It is described as a discretionary grant opportunity under the NIH umbrella with a health-related activity category.
When was the FOA created and what was the original closing date?
The FOA was created on November 23, 2016, and the original closing date was December 15, 2017.
What was the anticipated maximum award amount and number of awards?
The anticipated award ceiling was $499,999, and the FOA expected about 6 awards.
Which CFDA numbers are associated with this opportunity?
The announcement is associated with multiple CFDA numbers: 93.233, 93.837, 93.838, 93.839, and 93.840.
What does it mean that multiple CFDA numbers are listed?
Based on the FOA description, the multiple CFDA numbers reflect that the topic sits at the intersection of HIV research and multiple NIH mission areas connected to heart, lung, blood, and sleep research.
Who is eligible to apply?
Eligibility is broad and includes: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other entities as described in the FOA's additional eligibility language.
Are both nonprofit and for-profit organizations eligible?
Yes. The eligibility list includes nonprofit organizations (with or without 501(c)(3) status) and for-profit organizations (including small businesses and other for-profits, with the FOA listing separate categories).
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments and other Native American tribal organizations are included in the listed eligible applicants.
Are educational institutions eligible?
Yes. The FOA lists public and state-controlled institutions of higher education, private institutions of higher education, and independent school districts among eligible applicants.
What kinds of teams or institutions does the FOA appear to be trying to attract?
Based on the broad eligibility and the scientific requirements (clinical samples from HIV-infected patients plus integrated systems biology analysis), the FOA appears designed to attract multidisciplinary teams spanning academic medical centers, research institutes, government or public health-affiliated entities, and potentially industry or other research-capable organizations with access to appropriate HIV clinical cohorts and biospecimen resources.
Is access to HIV clinical cohorts and biospecimens important for competitiveness?
The FOA states that a central requirement is using clinical samples from HIV-infected patients and pairing them with robust clinical phenotyping. That implies applicants should be positioned to access appropriate patient-derived biospecimens and the related clinical outcome data needed to connect biology to HLBS and sleep outcomes.
What is the high-level outcome the FOA is trying to achieve?
The high-level aim is to clarify disease progression pathways that connect HIV infection to HLBS and sleep comorbidities and to generate knowledge that can point toward strategies and targets to prevent or delay these complications in people living with HIV.
Browse more opportunities from the same category: Health
Next opportunity: Cultural Landscape Preservation and Youth Engagement
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA HL 18 004
Applicants also applied for:
Applicants who have applied for this opportunity (RFA HL 18 004) also looked into and applied for these:
| Funding Opportunity |
|---|
| Limited Competition: NIH Health Care Systems Research Collaboratory - Coordinating Center (U24) Apply for RFA RM 16 018 Funding Number: RFA RM 16 018 Agency: Department of Health and Human Services, National Institutes of Health Category: Health Funding Amount: $2,000,000 |
| USAID/Haiti Request for Information on programming to improve the health status of communities across Haiti. Apply for RFI 521 17 000001 Funding Number: RFI 521 17 000001 Agency: Agency for International Development, Haiti USAID-Port Au Prince Category: Health Funding Amount: Case Dependent |
| Strengthening Surveillance in Jurisdictions with High Incidence of Hepatitis C Virus (HCV) and Hepatitis B Virus (HBV) Infections Apply for CDC RFA PS17 1703 Funding Number: CDC RFA PS17 1703 Agency: Department of Health and Human Services, Centers for Disease Control - NCHHSTP Category: Health Funding Amount: $350,000 |
| Autism CARES Act National Interdisciplinary Training Resource Center Apply for HRSA 17 010 Funding Number: HRSA 17 010 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Global Health Security Partnership Engagement: Expanding Efforts and Strategies to Protect and Improve Public Health Globally, Center for Global Health Apply for CDC RFA GH15 163202CONT17B Funding Number: CDC RFA GH15 163202CONT17B Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| National Maternal and Child Center for Oral Health Systems Integration and Improvement Apply for HRSA 17 086 Funding Number: HRSA 17 086 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Support for Health System Strengthening of Leadership, Governance and Quality Improvement in the Ministry of Health (MOH) in the Kingdom of Swaziland under the President’s Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH15 158403CONT17 Funding Number: CDC RFA GH15 158403CONT17 Agency: Department of Health and Human Services, Centers for Disease Control - CGH Category: Health Funding Amount: Case Dependent |
| Natural Experiments of Policy and Built Environment Impact on Diabetes Risk Apply for RFA DP 17 003 Funding Number: RFA DP 17 003 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $675,000 |
| Miner Safety and Health Training Program-Western United States (U60) Apply for RFA OH 17 006 Funding Number: RFA OH 17 006 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $400,000 |
| Conducting Public Health Activities in Egypt Apply for RFA GH 17 004 Funding Number: RFA GH 17 004 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $2,000,000 |
| Methamphetamine and Suicide Prevention Initiative - Generation Indigenous (Gen-I) Initiavite Support Apply for HHS 2017 IHS MSPI 0001 Funding Number: HHS 2017 IHS MSPI 0001 Agency: Department of Health and Human Services, Indian Health Service Category: Health Funding Amount: $400,000 |
| Autism Transitions Research Project (ATRP) Apply for HRSA 17 097 Funding Number: HRSA 17 097 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Frontier Community Health Integration Project Technical Assistance, Tracking, and Analysis Program Apply for HRSA 17 001 Funding Number: HRSA 17 001 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Research Grants for Preventing Violence and Violence Related Injury (R01) Apply for RFA CE 17 003 Funding Number: RFA CE 17 003 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $350,000 |
| Increasing Organ Donation Awareness Apply for HRSA 17 104 Funding Number: HRSA 17 104 Agency: Department of Health and Human Services, Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Addiction Technology Transfer Centers Cooperative Agreement (Short Title: ATTC) Apply for TI 17 005 Funding Number: TI 17 005 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Admin Category: Health Funding Amount: $1,175,294 |
| Community Characteristics Associated with Geographic Disparities in Diabetes and Cardiometabolic Health Apply for RFA DP 17 001 Funding Number: RFA DP 17 001 Agency: Department of Health and Human Services, Centers for Disease Control and Prevention - ERA Category: Health Funding Amount: $800,000 |
| Shared Instrumentation for Animal Research (SIFAR) Grant Program (S10) Apply for PAR 17 075 Funding Number: PAR 17 075 Agency: Department of Health and Human Services, National Institutes of Health Category: Health Funding Amount: $750,000 |
| USAID Community HIV Care and Treatment Activity Apply for RFA 663 17 000002 Funding Number: RFA 663 17 000002 Agency: Agency for International Development, Ethiopia USAID-Addis Ababa Category: Health Funding Amount: $40,000,000 |
| State Targeted Response to the Opioid Crisis Grants (Short Title: Opioid STR) Apply for TI 17 014 Funding Number: TI 17 014 Agency: Department of Health and Human Services, Substance Abuse and Mental Health Services Adminis Category: Health Funding Amount: $44,749,771 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA HL 18 004", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.