Opportunity Information: Apply for RFA HL 18 004
The Integrated Approaches to HIV-Related Heart, Lung, Blood, and Sleep (HLBS) Comorbidities (R01) funding opportunity (RFA-HL-18-004) is a National Institutes of Health (NIH) research grant announcement from the Department of Health and Human Services that supports hypothesis-driven, full-scale research projects using the R01 mechanism. The focus is on understanding why and how people living with HIV develop serious non-AIDS comorbidities affecting the heart, lungs, and blood system, as well as sleep disorders. Rather than studying these conditions in isolation, the FOA emphasizes integrated, systems biology style research that can connect molecular and cellular changes to clinical outcomes, with the bigger aim of clarifying disease progression pathways and pointing toward strategies that could prevent or delay these complications in HIV-infected populations.
A central requirement of the scientific approach is the use of clinical samples from HIV-infected patients. In practice, this points applicants toward studies that leverage patient-derived biospecimens (for example, blood, plasma/serum, immune cells, tissue samples when available, or other clinically collected materials) and pair them with robust clinical phenotyping of HLBS outcomes. The term "systems biology" signals an expectation for multi-layered biological measurement and integrative analysis, such as combining genomics, transcriptomics, epigenomics, proteomics, metabolomics, immune profiling, or microbiome-related data (as appropriate) with computational modeling to identify networks and perturbations associated with HLBS comorbidities in HIV. The intent is to move beyond single biomarkers and instead map out interconnected pathways that may explain increased risk, earlier onset, or accelerated progression of HLBS diseases and sleep disorders among people living with HIV, including those receiving antiretroviral therapy.
The ultimate goal described in the announcement is translational in the sense that it seeks mechanistic insight that can reveal actionable biology. By identifying the biological perturbations linked to HLBS comorbidities, the research is expected to help uncover new therapeutic targets or intervention points, ideally ones that can be used to pre-empt disease onset rather than only treating established disease. In other words, the FOA is aimed at understanding what changes in biology occur in HIV that set the stage for cardiovascular disease, pulmonary complications, hematologic abnormalities, and sleep-related disorders, and then using that understanding to inform future preventative or early-intervention strategies.
From an administrative standpoint, this is a discretionary grant opportunity under the NIH umbrella with a health-related activity category. The FOA was created on November 23, 2016, with an original closing date of December 15, 2017. The anticipated scale of support included an award ceiling of $499,999, with an expectation of about 6 awards. The announcement is associated with multiple CFDA numbers (93.233, 93.837, 93.838, 93.839, 93.840), reflecting that the topic sits at the intersection of HIV and multiple NIH mission areas connected to heart, lung, blood, and sleep research.
Eligibility is broad and includes many types of organizations that commonly apply to NIH opportunities. Eligible applicants listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other entities as described in the FOA’s additional eligibility language. This wide eligibility suggests NIH was seeking to attract multidisciplinary teams spanning academic medical centers, research institutes, public health and government-affiliated entities, and potentially industry or other research-capable organizations with access to appropriate HIV clinical cohorts and biospecimen resources.
In short, this R01 opportunity funds integrated, patient-sample-based systems biology research designed to explain the biological mechanisms that link HIV infection to higher rates and different trajectories of heart, lung, blood, and sleep comorbidities, with an emphasis on generating knowledge that can ultimately guide the identification of preventative therapeutic targets for people living with HIV.Apply for RFA HL 18 004
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Integrated Approaches to HIV-Related Heart, Lung, Blood, and Sleep (HLBS) Comorbidities (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840.
- This funding opportunity was created on Nov 23, 2016.
- Applicants must submit their applications by Dec 15, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $499,999.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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