Opportunity Information: Apply for RFA NS 22 013
This NIH funding opportunity (RFA-NS-22-013) is a limited competition cooperative agreement (U24; clinical trial not allowed) to support the Data Coordinating Center (DCC) for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network, known as SIREN. The overall goal of SIREN is to make it feasible to run high-quality, multi-site, real-world clinical trials in emergency care environments, specifically targeting urgent neurologic, cardiac, respiratory, hematologic, and trauma events. In practical terms, the network is designed to improve patient outcomes in situations where care is time-sensitive and difficult to study, such as in the emergency department and pre-hospital settings like EMS.
SIREN is structured as a coordinated national network with three main components: one Clinical Coordinating Center (CCC), one Data Coordinating Center (DCC), and up to 10 clinical centers referred to as Hubs. The DCC being solicited under this announcement functions as the central backbone for the network's data and analytics operations. Its core responsibilities include building and maintaining the systems and processes for study data capture and management, ensuring data quality and integrity across participating sites, conducting statistical planning and analyses, and supporting safety oversight through Data Safety Monitoring Board (DSMB) operations. The DCC is also expected to handle reporting obligations to regulatory and oversight bodies, meaning it serves as a key interface for compliance-focused documentation and standardized reporting across the network.
A central expectation of the SIREN program is the execution of at least four large, simple, pragmatic clinical trials, each enrolling roughly 1,000 patients, conducted in emergency department and pre-hospital environments. These trials are intended to be practical and scalable, emphasizing streamlined protocols and real-world implementation rather than highly specialized or narrowly controlled studies. Importantly, the individual clinical trial projects themselves are not funded under this specific DCC announcement; instead, they are described as meritorious, peer-reviewed studies that will be competed and awarded under separate funding announcements. The DCC awardee must therefore be prepared to support multiple trials over time that may vary in clinical focus but share the operational constraints and fast-paced decision-making typical of emergency care research.
From an administrative standpoint, this opportunity is a cooperative agreement, which generally means NIH anticipates substantial scientific and programmatic involvement in the conduct of the award compared to a standard grant. The activity category is health, and the opportunity references multiple CFDA numbers (93.233, 93.837, 93.838, 93.839, 93.840, 93.853), reflecting its alignment with NIH institutes and programs involved in emergency and acute care research domains. The listed eligible applicant type includes public and state-controlled institutions of higher education, and the announcement explicitly restricts foreign involvement: non-U.S. institutions may not apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed.
Key dates and funding parameters provided in the source data include an original closing date of January 18, 2022, and an award ceiling of $290,000 (as presented in the extracted listing). The opportunity was created on November 19, 2021. Applicants considering this FOA would need to focus their proposal on demonstrating the capacity to serve as a high-functioning coordinating center for a complex, multi-site emergency care trials network, with strong infrastructure for data systems, statistical leadership, DSMB and safety monitoring support, and reliable regulatory reporting, all tailored to the operational realities of emergency and pre-hospital research.Apply for RFA NS 22 013
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Network for Emergency Care Clinical Trials: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Data Coordinating Center (DCC) (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840, 93.853.
- This funding opportunity was created on 2021-11-19.
- Applicants must submit their applications by 2022-01-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $290,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education.
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Apply for RFA NS 22 013
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