Opportunity Information: Apply for RFA TR 24 021
This funding opportunity (RFA-TR-24-021) is a discretionary NIH cooperative agreement intended to support the continued operation of the Data Management and Coordinating Center (DMCC) for the Rare Diseases Clinical Research Network (RDCRN). It is explicitly non-competitive and designed to result in a single award, with the National Center for Advancing Translational Sciences (NCATS) stating its intent to make a sole-source award to Cincinnati Childrens Hospital Medical Center (CCHMC). The mechanism is a U2C cooperative agreement and the notice specifies that clinical trials are not allowed under this particular award.
The RDCRN itself is a national, collaborative research network focused on improving the diagnosis, management, and treatment of a wide range of rare diseases. Its model emphasizes multi-site coordination, strong collaboration across institutions and stakeholders, and patient-centric translational and clinical research. A key theme of the network is accelerating early and timely identification of individuals with rare diseases and ensuring the infrastructure and coordination needed for clinical trial readiness across rare disease areas, even though this specific DMCC award is not for running clinical trials.
Within that broader network, the DMCC serves as the operational backbone that enables multiple Rare Diseases Clinical Research Consortia (RDCRCs) to function efficiently and consistently. The DMCC role is described as supporting both consortium-specific needs and cross-network activities that help advance rare disease research overall. The opportunity highlights four main avenues of DMCC support: (1) administrative support to keep the network organized and compliant, (2) data management support to handle the complex, multi-site data needs typical of rare disease research, (3) clinical research support and patient engagement to facilitate study operations and meaningful participation by patients and communities, and (4) broad dissemination of information so that findings, resources, and network outputs are shared widely and can be used by researchers, clinicians, and patient groups. Importantly, the RDCRCs themselves will continue conducting their research under a separate notice of funding opportunity, meaning this award is centered on coordination and enabling infrastructure rather than directly funding the consortia research projects.
Eligibility is tightly constrained because of the single-source intent. While the listing includes eligible applicant categories such as public and state-controlled institutions of higher education, the narrative makes clear that NCATS plans to fund only one specific recipient (CCHMC). Foreign organizations are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed, which generally means limited, well-justified foreign involvement can be included as part of an otherwise eligible U.S.-based project when consistent with NIH policy and the award’s scope.
Administratively, the opportunity was created on 2024-04-05 and lists an original closing date of 2024-07-22. It is categorized under health and references CFDA numbers 93.350 and 93.853. The posting does not provide an award ceiling or an expected number of awards in the provided excerpt, but the description makes the expected outcome clear: one cooperative agreement award supporting continued DMCC operations for the RDCRN.Apply for RFA TR 24 021
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Single Source for the Continuation of the Data Management and Coordinating Center (DMCC) for Rare Diseases Clinical Research Network (RDCRN) (U2C Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.350, 93.853.
- This funding opportunity was created on 2024-04-05.
- Applicants must submit their applications by 2024-07-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education.
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Frequently Asked Questions (FAQs) - RFA-TR-24-021 (RDCRN DMCC)
What is the funding opportunity number and what does it support?
This opportunity is RFA-TR-24-021. It is an NIH discretionary cooperative agreement intended to support the continued operation of the Data Management and Coordinating Center (DMCC) for the Rare Diseases Clinical Research Network (RDCRN).
Is this a competitive funding opportunity?
No. The notice explicitly describes the opportunity as non-competitive and designed to result in a single award.
How many awards are expected under this notice?
Based on the notice language, the expected outcome is one cooperative agreement award to support continued RDCRN DMCC operations.
Who does NCATS intend to fund under this opportunity?
NCATS states its intent to make a sole-source award to Cincinnati Childrens Hospital Medical Center (CCHMC).
What NIH mechanism is being used for this award?
The mechanism is a U2C cooperative agreement.
Are clinical trials allowed under this award?
No. The notice specifies that clinical trials are not allowed under this particular award.
What is the RDCRN?
The Rare Diseases Clinical Research Network (RDCRN) is a national, collaborative research network focused on improving the diagnosis, management, and treatment of a wide range of rare diseases through multi-site coordination, collaboration across institutions and stakeholders, and patient-centric translational and clinical research.
If clinical trials are not allowed, why does the notice mention clinical trial readiness?
The RDCRN emphasizes infrastructure and coordination needed for clinical trial readiness across rare disease areas. Even though this specific DMCC award is not for running clinical trials, it supports the enabling backbone that helps the network operate consistently and be prepared for clinical research activities conducted under other mechanisms.
What is the DMCC and what does it do within the RDCRN?
The DMCC is described as the operational backbone of the RDCRN. It enables multiple Rare Diseases Clinical Research Consortia (RDCRCs) to function efficiently and consistently by supporting both consortium-specific needs and cross-network activities.
What are the main areas of support the DMCC provides?
The opportunity highlights four main avenues of DMCC support: (1) administrative support to keep the network organized and compliant, (2) data management support for complex multi-site data needs, (3) clinical research support and patient engagement to facilitate study operations and meaningful participation, and (4) broad dissemination of information so findings and resources are shared widely.
Does this award directly fund rare disease research projects run by consortia?
No. The excerpt indicates that the RDCRCs will continue conducting their research under a separate notice of funding opportunity. This award is centered on coordination and enabling infrastructure rather than directly funding the consortia research projects.
What types of organizations are listed as eligible applicants?
The listing includes eligible applicant categories such as public and state-controlled institutions of higher education. However, the narrative makes clear that the intent is to make a sole-source award to one specific recipient (CCHMC).
Are foreign organizations eligible to apply?
No. Foreign organizations are not eligible to apply under this opportunity.
Are non-U.S. components of U.S. organizations eligible?
No. The notice states that non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed at all?
Yes. The opportunity states that foreign components (as defined in the NIH Grants Policy Statement) are allowed. This generally refers to limited, well-justified foreign involvement included as part of an otherwise eligible U.S.-based project, consistent with NIH policy and the award scope.
Who is the sponsoring NIH center or institute for this notice?
The notice identifies the National Center for Advancing Translational Sciences (NCATS).
When was this opportunity created?
The opportunity was created on 2024-04-05.
What is the original closing date listed in the notice?
The original closing date listed is 2024-07-22.
What general category does this opportunity fall under?
It is categorized under health.
What CFDA numbers are referenced for this opportunity?
The notice references CFDA numbers 93.350 and 93.853.
Is an award ceiling or budget limit provided in the excerpt?
No. The provided excerpt does not include an award ceiling.
Does the excerpt state the expected number of awards?
The excerpt does not list an expected number of awards as a numeric field, but the narrative indicates the intent to make a single, sole-source award.
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