Opportunity Information: Apply for CDC RFA GH21 2101
The grant opportunity titled "Support of Global Polio Eradication Initiative (GPEI) using Integrated Modeling" is a CDC cooperative agreement meant to strengthen the evidence base behind late-stage polio eradication decisions. It sits within the long-running Global Polio Eradication Initiative, launched in 1988, where CDC is one of the core partners alongside WHO, UNICEF, Rotary International, the Bill and Melinda Gates Foundation, and Gavi. The context for the award is that polio eradication has reached a narrow but complicated endgame: by 2020, wild poliovirus (WPV) transmission had been reduced from 125 countries in 1988 to only two countries, Afghanistan and Pakistan. WPV types 2 and 3 are already certified eradicated, leaving WPV type 1 as the remaining wild strain, and five of the six WHO regions have been certified WPV-free (with the Eastern Mediterranean Region still pending, reflecting the ongoing transmission in Afghanistan and Pakistan).
The opportunity is driven by two pressing challenges that now dominate global polio strategy. The first is interrupting the remaining WPV1 transmission in Afghanistan and Pakistan, where operational constraints, insecurity, access issues, and immunity gaps can sustain transmission despite years of vaccination effort. The second is the growing problem of circulating vaccine-derived polioviruses (cVDPVs), especially type 2 (cVDPV2). These outbreaks can occur when the live attenuated virus in the oral polio vaccine (OPV) circulates for extended periods in under-immunized communities, gradually evolving in a way that can restore neurovirulence and transmissibility. As eradication nears, the program must balance the strong outbreak-control benefits of OPV with the fact that continued OPV use can itself seed future cVDPV outbreaks if population immunity is not high and consistent.
The CDC is seeking a recipient that can expand and apply integrated modeling to inform these high-stakes policy choices. The work builds on a long-standing collaboration between CDC and Kid Risk, which has supported eradication planning for roughly two decades and most recently operated under cooperative agreement NU2RGH001913. Under that prior work, the modeling platform was updated into a global integrated framework that combines dynamic disease transmission modeling with risk and economic components. The model is designed to represent real-world complexities that matter in the endgame, including differences by poliovirus serotype, multiple transmission routes, routine immunization schedules, the evolutionary behavior of Sabin OPV viruses during transmission, and the mechanisms that lead to cVDPV emergence, with particular emphasis on cVDPV2.
The summary of recent modeling contributions gives a sense of what the new award is intended to continue and deepen. In 2019, modeling focused on the specific question of whether WPV transmission had truly stopped in parts of northeast Nigeria (Borno and Yobe states) and how confident decision-makers could be given surveillance limitations and the challenges of detecting silent transmission. That work supported the deliberations of the Africa Region Certification Commission ahead of the region being certified WPV-free in August 2020. In 2020, the modeling shifted to reflect the changing cVDPV2 landscape, examining how different outbreak response strategies could affect risk, including scenarios that might force a restart of Sabin type 2 in routine immunization, and evaluating possible outcomes associated with wider deployment of a novel, more genetically stabilized type 2 OPV (often discussed as a tool intended to reduce the chance of seeding new cVDPV2 outbreaks while still controlling existing ones).
At its core, this funding announcement is about generating timely, decision-ready analysis for the remaining polio eradication endgame problems. It calls for modeling of new vaccine strategies and response approaches, especially around preventing and stopping VDPV2 outbreaks while moving toward the eventual withdrawal of Sabin OPV use altogether. It also explicitly highlights the continued need for modeling that can guide strategies to finally eliminate WPV1 in Afghanistan and Pakistan. In addition to polio, the announcement notes that the awardee may be asked to address modeling questions relevant to control and elimination of other vaccine-preventable diseases, reflecting CDC interests in applying similar analytic approaches beyond polio where integrated transmission, risk, and economic modeling can inform immunization policy and outbreak preparedness.
Administratively, the opportunity is a discretionary cooperative agreement (meaning substantial involvement and collaboration with CDC is expected rather than a hands-off grant). It was issued by the Department of Health and Human Services, Centers for Disease Control and Prevention, Center for Global Health, under Funding Opportunity Number CDC RFA GH21 2101 and CFDA 93.185. The notice anticipated a single award (Expected Awards: 1). The posting lists an award ceiling of 0, which typically indicates the ceiling was not specified in the summary field rather than implying no funding, and applicants would need to consult the full announcement for budget expectations and constraints. The original application due date was February 11, 2021, with electronic submissions due by 11:59 p.m. ET. Eligibility is described broadly as "Others" with additional clarification referenced in the full eligibility text.Apply for CDC RFA GH21 2101
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Support of Global Polio Eradication Initiative (GPEI) using Integrated Modeling" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.185.
- This funding opportunity was created on Dec 11, 2020.
- Applicants must submit their applications by Feb 11, 2021 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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