Opportunity Information: Apply for CDC RFA GH18 1814
This funding opportunity (CDC RFA GH18-1814) is a PEPFAR-supported cooperative agreement from the Centers for Disease Control and Prevention (CDC), Center for Global Health, focused on reducing HIV transmission and other transfusion-transmitted infections by strengthening national blood transfusion systems in selected countries. The overall aim is to help National Blood Transfusion Services (NBTS) deliver blood and blood components that meet global standards for safety and quality, while also improving how blood donors with HIV-reactive screening results are identified, referred, traced, and linked to appropriate HIV testing and treatment services.
A central part of the work is improving the entire "vein-to-vein" blood safety chain, meaning the full pathway from the donor to the recipient. The opportunity emphasizes stronger donor management and risk reduction through behavioral screening and by expanding and retaining a stable base of regular, voluntary, non-remunerated, low-risk donors. This reflects the widely accepted public health approach that a consistent pool of voluntary donors, combined with appropriate screening, helps reduce infection risk more reliably than relying on paid or replacement donors.
On the technical side, the FOA prioritizes upgrading the quality and consistency of blood collection, processing, and laboratory testing. That includes ensuring that collected blood is handled using quality-assured procedures, and that testing for transfusion-transmissible infections is performed to appropriate standards so infected units are reliably identified and removed from the supply. It also highlights blood component production, which involves separating whole blood into components (such as red cells, plasma, and platelets) to improve clinical outcomes and make better use of each donation, while maintaining strong quality controls across each step.
The opportunity also targets safer and more appropriate clinical use of blood. This typically involves strengthening clinical guidelines, clinician training, and hospital transfusion practices so that blood is used only when medically necessary and in the safest manner possible. Alongside this, it promotes haemovigilance, meaning systems for monitoring, investigating, and learning from adverse transfusion reactions and other transfusion-related events. A functioning haemovigilance system helps identify gaps in practice, supports continuous quality improvement, and ultimately protects patients.
Another major emphasis is strengthening referral pathways for donors whose blood screens HIV-reactive. The FOA calls for increased capacity to ensure adequate referral and tracing so these donors can be connected to HIV testing and counseling (HTC) programs for prevention counseling, confirmatory testing, and linkage to treatment services. The intention is not only to protect the blood supply by identifying reactive donations, but also to make sure individuals receive timely follow-up care, which supports both individual health outcomes and broader HIV prevention goals.
By improving quality assurance across NBTS operations, reinforcing safety standards, and making follow-up and linkage-to-care more consistent for HIV-reactive donors, the grant is designed to support a reliable, quality-assured blood supply while contributing to PEPFAR epidemic control priorities, including progress toward the 90-90-90 targets (diagnosing people living with HIV, treating those diagnosed, and achieving viral suppression among those on treatment).
Administratively, the program is offered as a discretionary cooperative agreement, indicating substantial involvement from CDC in program implementation and technical direction. It is listed under CFDA 93.067, was open to unrestricted eligible applicants, had an original closing date of October 15, 2017, and projected up to two awards, with an award ceiling of $1,270,000.Apply for CDC RFA GH18 1814
- The Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Technical Assistance Support for the Strengthening of Blood Transfusion Services to Decrease HIV and Other Transfusion Transmitted Infections in Selected Countries under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on 2017-08-15.
- Applicants must submit their applications by 2017-10-15. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,270,000.00 in funding.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Unrestricted.
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Frequently Asked Questions (FAQs)
1) What is CDC RFA GH18-1814?
CDC RFA GH18-1814 is a PEPFAR-supported discretionary cooperative agreement from the Centers for Disease Control and Prevention (CDC), Center for Global Health. It focuses on reducing HIV transmission and other transfusion-transmitted infections by strengthening national blood transfusion systems in selected countries.
2) What is the main purpose of this funding opportunity?
The overall aim is to help National Blood Transfusion Services (NBTS) deliver blood and blood components that meet global standards for safety and quality. It also aims to improve how blood donors with HIV-reactive screening results are identified, referred, traced, and linked to appropriate HIV testing and treatment services.
3) What kinds of infections are targeted by this work?
The opportunity is centered on reducing HIV transmission and other transfusion-transmitted infections through improvements in blood safety, screening, and quality systems.
4) Who is this program intended to support?
The work is intended to strengthen National Blood Transfusion Services (NBTS) and the broader national blood transfusion system, including donor management, blood collection and processing, laboratory testing, and clinical transfusion practices.
5) What does "vein-to-vein" mean in this grant?
"Vein-to-vein" refers to the complete blood safety chain from the donor to the recipient. In practice, it means improving quality and safety across every step of the pathway, not just one part of the system.
6) How does the opportunity address blood donor recruitment and retention?
The FOA emphasizes stronger donor management and risk reduction through behavioral screening and by expanding and retaining a stable base of regular, voluntary, non-remunerated, low-risk donors. The underlying approach reflects the public health consensus that a consistent pool of voluntary donors, combined with appropriate screening, reduces infection risk more reliably than paid or replacement donors.
7) What role does behavioral screening play in the program?
Behavioral screening is highlighted as a risk-reduction strategy within donor management. It supports identifying low-risk donors and strengthening donor selection practices to improve the safety of the blood supply.
8) What technical improvements to blood collection and processing are prioritized?
The opportunity prioritizes improving the quality and consistency of blood collection, processing, and laboratory testing. This includes ensuring that collected blood is handled using quality-assured procedures and that operations align with appropriate safety and quality standards.
9) What does the grant say about laboratory testing?
Laboratory testing for transfusion-transmissible infections is emphasized so that infected units are reliably identified and removed from the blood supply. The focus is on testing being performed to appropriate standards with consistent quality.
10) Does the opportunity support blood component production?
Yes. The FOA highlights blood component production, including separating whole blood into components such as red cells, plasma, and platelets. This is intended to improve clinical outcomes and make better use of each donation, while maintaining strong quality controls at each step.
11) How does the funding opportunity address clinical use of blood?
It targets safer and more appropriate clinical use of blood by strengthening clinical guidelines, clinician training, and hospital transfusion practices. The intent is to support the use of blood only when medically necessary and in the safest manner possible.
12) What is haemovigilance, and why is it included?
Haemovigilance refers to systems for monitoring, investigating, and learning from adverse transfusion reactions and other transfusion-related events. A functioning haemovigilance system helps identify gaps in practice, supports continuous quality improvement, and protects patients.
13) How does the grant address donors with HIV-reactive screening results?
A major emphasis is strengthening referral pathways for donors whose blood screens HIV-reactive. The FOA calls for increased capacity to ensure adequate referral and tracing so these donors can be connected to HIV testing and counseling (HTC) programs for prevention counseling, confirmatory testing, and linkage to treatment services.
14) What does "referral and tracing" mean in this context?
Within the FOA, referral and tracing relates to ensuring donors with HIV-reactive screening results are identified and followed up so they can be connected to appropriate HIV services, including confirmatory testing and linkage to care.
15) Why does the opportunity focus on linkage to HIV testing and treatment?
The intention is twofold: protect the blood supply by identifying reactive donations and ensure individuals receive timely follow-up care. This supports individual health outcomes and broader HIV prevention goals.
16) How does this grant align with PEPFAR priorities?
The grant is designed to support a reliable, quality-assured blood supply while contributing to PEPFAR epidemic control priorities, including progress toward the 90-90-90 targets: diagnosing people living with HIV, treating those diagnosed, and achieving viral suppression among those on treatment.
17) What type of grant mechanism is this?
This program is a discretionary cooperative agreement. That means CDC is expected to have substantial involvement in program implementation and technical direction.
18) What does "substantial involvement" by CDC typically imply?
Based on the cooperative agreement structure described, CDC involvement includes program implementation support and technical direction, rather than a hands-off role.
19) What is the CFDA number for this opportunity?
The opportunity is listed under CFDA 93.067.
20) Who was eligible to apply?
The funding opportunity was open to unrestricted eligible applicants, as stated in the opportunity description.
21) What was the application deadline?
The original closing date was October 15, 2017.
22) How many awards were anticipated?
The opportunity projected up to two awards.
23) What was the maximum award amount?
The award ceiling was $1,270,000.
24) What are the key system areas this grant aims to strengthen?
Key areas described include donor management and risk reduction, quality-assured blood collection and processing, laboratory testing standards for transfusion-transmissible infections, blood component production with quality controls, safer clinical transfusion practices, haemovigilance systems, and structured referral/tracing and linkage-to-care for donors with HIV-reactive screening results.
25) What is the expected impact of strengthening NBTS operations under this opportunity?
By improving quality assurance across NBTS operations, reinforcing safety standards, and making follow-up and linkage-to-care more consistent for HIV-reactive donors, the program is designed to support a reliable, quality-assured blood supply and reduce the risk of HIV and other transfusion-transmitted infections.
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