Opportunity Information: Apply for CDC RFA CK21 2104
The Global Healthcare Detection and Response opportunity (CDC RFA CK21-2104) is a CDC-led cooperative agreement aimed at strengthening how healthcare facilities around the world identify and stop emerging infectious disease threats. The underlying idea is straightforward: hospitals, clinics, and other care settings are often where outbreaks can be detected early, but they can also become places where infections spread quickly if systems are weak. By improving infection detection and response inside healthcare settings, this program is meant to reduce the impact of emerging infections, slow the spread of antibiotic-resistant organisms, and help ensure essential medical care can keep functioning during health emergencies.
A central feature of the program is its network model. Rather than funding isolated efforts, the CDC is promoting a global collaborative network where partners align around targeted prevention priorities. Those priorities may focus on specific pathogens or urgent conditions (for example, high-consequence emerging infections or resistant organisms), and the network is expected to work collectively toward shared goals. The emphasis is on rapid detection paired with active containment in healthcare settings, meaning grantees are not only expected to find problems earlier, but also to be prepared to act quickly to prevent further spread within and between facilities.
The work described in the notice covers several interconnected components that operate at local, national, and regional levels. Grantees are expected to implement or strengthen practical detection and response services in healthcare facilities, then continually evaluate how well those services are working. That includes ongoing monitoring of implementation, assessing outcomes and impact, and using the results to improve performance over time rather than treating the project as a one-time build. The opportunity also highlights implementation science and innovation, signaling that recipients should test and refine strategies in real-world settings, document what works and why, and use evidence to guide scale-up and adaptation across different healthcare contexts.
Laboratory capacity is another major pillar. Because detection and containment depend heavily on timely and reliable testing, the program calls for enhancing laboratory capability at key participating labs. This can include improving diagnostic readiness for priority pathogens, strengthening quality systems, and ensuring labs are effectively integrated into facility and public health response workflows. The notice also explicitly emphasizes learning and knowledge-sharing beyond the immediate awardees, with recipients expected to actively facilitate the spread of lessons learned to other partners in the same country or region. In practice, that points to training, mentorship, shared protocols, and other mechanisms that help expand capability beyond a single site.
Administratively, this is a discretionary funding opportunity from the Department of Health and Human Services, Centers for Disease Control and Prevention (specifically CDC NCEZID), offered as a cooperative agreement, which typically means substantial programmatic involvement from CDC compared with a standard grant. The CFDA (now commonly referred to as Assistance Listing) number is 93.318. Eligibility is listed as unrestricted, meaning a broad range of organizations may apply, subject to any additional eligibility details that may be included in the full notice. The opportunity was created April 16, 2021, with an original application deadline of June 15, 2021 (applications due by 11:59 p.m. Eastern Time). The notice indicates an expectation of roughly 40 awards, and the award ceiling is listed as 0, which generally suggests the ceiling was not specified in the summary field and would need to be confirmed in the full funding announcement text or related budget guidance.
Overall, the grant focuses on building a coordinated, continually improving system for detecting and containing infectious threats inside healthcare facilities, backed by stronger laboratories, measurable implementation and impact tracking, and active cross-site learning so gains can spread across a country or region rather than staying limited to a few participating institutions.Apply for CDC RFA CK21 2104
- The Department of Health and Human Services, Centers for Disease Control - NCEZID in the health sector is offering a public funding opportunity titled "Global Healthcare Detection and Response" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.318.
- This funding opportunity was created on Apr 16, 2021.
- Applicants must submit their applications by Jun 15, 2021 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 40 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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