Opportunity Information: Apply for CDC RFA CK21 2104
The Global Healthcare Detection and Response opportunity (CDC RFA CK21-2104) is a CDC-led cooperative agreement aimed at strengthening how healthcare facilities around the world identify and stop emerging infectious disease threats. The underlying idea is straightforward: hospitals, clinics, and other care settings are often where outbreaks can be detected early, but they can also become places where infections spread quickly if systems are weak. By improving infection detection and response inside healthcare settings, this program is meant to reduce the impact of emerging infections, slow the spread of antibiotic-resistant organisms, and help ensure essential medical care can keep functioning during health emergencies.
A central feature of the program is its network model. Rather than funding isolated efforts, the CDC is promoting a global collaborative network where partners align around targeted prevention priorities. Those priorities may focus on specific pathogens or urgent conditions (for example, high-consequence emerging infections or resistant organisms), and the network is expected to work collectively toward shared goals. The emphasis is on rapid detection paired with active containment in healthcare settings, meaning grantees are not only expected to find problems earlier, but also to be prepared to act quickly to prevent further spread within and between facilities.
The work described in the notice covers several interconnected components that operate at local, national, and regional levels. Grantees are expected to implement or strengthen practical detection and response services in healthcare facilities, then continually evaluate how well those services are working. That includes ongoing monitoring of implementation, assessing outcomes and impact, and using the results to improve performance over time rather than treating the project as a one-time build. The opportunity also highlights implementation science and innovation, signaling that recipients should test and refine strategies in real-world settings, document what works and why, and use evidence to guide scale-up and adaptation across different healthcare contexts.
Laboratory capacity is another major pillar. Because detection and containment depend heavily on timely and reliable testing, the program calls for enhancing laboratory capability at key participating labs. This can include improving diagnostic readiness for priority pathogens, strengthening quality systems, and ensuring labs are effectively integrated into facility and public health response workflows. The notice also explicitly emphasizes learning and knowledge-sharing beyond the immediate awardees, with recipients expected to actively facilitate the spread of lessons learned to other partners in the same country or region. In practice, that points to training, mentorship, shared protocols, and other mechanisms that help expand capability beyond a single site.
Administratively, this is a discretionary funding opportunity from the Department of Health and Human Services, Centers for Disease Control and Prevention (specifically CDC NCEZID), offered as a cooperative agreement, which typically means substantial programmatic involvement from CDC compared with a standard grant. The CFDA (now commonly referred to as Assistance Listing) number is 93.318. Eligibility is listed as unrestricted, meaning a broad range of organizations may apply, subject to any additional eligibility details that may be included in the full notice. The opportunity was created April 16, 2021, with an original application deadline of June 15, 2021 (applications due by 11:59 p.m. Eastern Time). The notice indicates an expectation of roughly 40 awards, and the award ceiling is listed as 0, which generally suggests the ceiling was not specified in the summary field and would need to be confirmed in the full funding announcement text or related budget guidance.
Overall, the grant focuses on building a coordinated, continually improving system for detecting and containing infectious threats inside healthcare facilities, backed by stronger laboratories, measurable implementation and impact tracking, and active cross-site learning so gains can spread across a country or region rather than staying limited to a few participating institutions.Apply for CDC RFA CK21 2104
- The Department of Health and Human Services, Centers for Disease Control - NCEZID in the health sector is offering a public funding opportunity titled "Global Healthcare Detection and Response" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.318.
- This funding opportunity was created on Apr 16, 2021.
- Applicants must submit their applications by Jun 15, 2021 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 40 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs): Global Healthcare Detection and Response (CDC RFA CK21-2104)
What is the Global Healthcare Detection and Response opportunity (CDC RFA CK21-2104)?
It is a CDC-led cooperative agreement focused on strengthening how healthcare facilities identify and stop emerging infectious disease threats. The program centers on improving detection and response inside hospitals, clinics, and other care settings so outbreaks can be found earlier and contained faster.
What problem is this program trying to solve?
The opportunity addresses the reality that healthcare facilities can be the first place outbreaks are detected, but they can also amplify spread if systems are weak. By strengthening detection and containment in care settings, the program aims to reduce the impact of emerging infections, slow the spread of antibiotic-resistant organisms, and help essential medical care continue during health emergencies.
What type of funding mechanism is this?
This is a discretionary funding opportunity from the U.S. Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), specifically CDC NCEZID. The award mechanism is a cooperative agreement, which typically involves substantial programmatic involvement from CDC compared to a standard grant.
What is the main goal of the program?
The main goal is to build a coordinated system within healthcare settings for rapid detection and active containment of infectious threats, supported by strong laboratories, ongoing monitoring and evaluation, and deliberate knowledge-sharing so improvements spread across facilities and regions.
What does "rapid detection paired with active containment" mean in this program?
It means grantees are expected not only to identify emerging infectious threats earlier, but also to be prepared to act quickly to prevent further spread within a facility and between facilities.
What is the network model mentioned in the opportunity?
Rather than funding isolated efforts, the program promotes a global collaborative network. Partners align around targeted prevention priorities and work collectively toward shared goals, including coordinated learning and cross-site collaboration.
What kinds of prevention priorities might the network focus on?
The notice indicates priorities may focus on specific pathogens or urgent conditions, such as high-consequence emerging infections or antibiotic-resistant organisms.
At what levels is the work expected to operate?
The work described spans local, national, and regional levels, reflecting the intent to strengthen facility-based systems while also supporting broader coordination and shared learning across a country or region.
What activities are grantees expected to implement or strengthen in healthcare facilities?
Grantees are expected to implement or strengthen practical detection and response services in healthcare facilities and to continually evaluate how well those services are working, using results to improve performance over time.
Does the program emphasize monitoring and evaluation?
Yes. The opportunity highlights ongoing monitoring of implementation, assessment of outcomes and impact, and continuous improvement. The intent is for performance tracking and refinement to be ongoing rather than treated as a one-time build.
What does the opportunity mean by "implementation science and innovation"?
Recipients are expected to test and refine strategies in real-world healthcare settings, document what works and why, and use evidence to guide scale-up and adaptation across different healthcare contexts.
Why is laboratory capacity a major pillar of this program?
Detection and containment depend on timely and reliable testing. The program calls for enhancing laboratory capability at key participating labs so diagnostic readiness, quality systems, and integration with facility and public health response workflows are strengthened.
What kinds of lab improvements are referenced in the opportunity?
Examples mentioned include improving diagnostic readiness for priority pathogens, strengthening laboratory quality systems, and ensuring labs are effectively integrated into healthcare facility and public health response workflows.
How does the program expect knowledge and lessons learned to be shared?
Recipients are expected to actively facilitate sharing beyond immediate awardees, helping spread lessons learned to other partners in the same country or region. The notice points to mechanisms like training, mentorship, shared protocols, and other approaches that expand capability beyond a single site.
Who is eligible to apply?
Eligibility is listed as unrestricted, meaning a broad range of organizations may apply, subject to any additional eligibility details that may be included in the full funding notice.
What is the Assistance Listing (CFDA) number for this opportunity?
The CFDA (Assistance Listing) number is 93.318.
When was this opportunity created and what was the application deadline?
The opportunity was created on April 16, 2021. The original application deadline was June 15, 2021, with applications due by 11:59 p.m. Eastern Time.
How many awards does the notice expect to make?
The notice indicates an expectation of roughly 40 awards.
Is there an award ceiling (maximum award amount) listed?
The award ceiling is listed as 0 in the summary, which generally suggests the ceiling was not specified in that field. The actual maximum award amount would need to be confirmed in the full funding announcement text or related budget guidance.
What makes this a "cooperative agreement" rather than a standard grant?
The notice describes it as a cooperative agreement, which typically indicates CDC will have substantial programmatic involvement in the work compared with a standard grant arrangement.
What is the overall intended outcome of the program?
The overall intent is to build a coordinated, continually improving system for detecting and containing infectious threats inside healthcare facilities, backed by stronger laboratories, measurable tracking of implementation and impact, and active cross-site learning so gains spread across a country or region.
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