Opportunity Information: Apply for PAR 21 126
The High-End Instrumentation (HEI) Grant Program (Funding Opportunity Number PAR-21-126) is a National Institutes of Health (NIH) discretionary grant opportunity under the Department of Health and Human Services. It is designed to help groups of investigators who already hold NIH support acquire or upgrade one major piece of expensive, specialized, commercially available research equipment, or an integrated instrumentation system. A central idea of the program is shared use: the application is expected to be driven by a consortium or group of NIH-funded researchers who can clearly show that a single, high-end instrument will substantially strengthen the research capabilities of multiple projects and users, rather than serving only one lab.
The program focuses specifically on high-end instrumentation purchases or upgrades, with awards starting at a minimum of $600,001 and a maximum award amount of $2,000,000. While the instrument itself can cost more than $2,000,000 (there is no stated maximum price limit for the instrument), the NIH award will not exceed the $2,000,000 ceiling, meaning applicants may need to cover remaining costs through institutional funds, cost sharing, or other sources if the total price goes beyond the award cap. The opportunity anticipates making around 25 awards, indicating a competitive selection process.
Supported instruments span a wide range of advanced biomedical and life-science technologies. Examples explicitly highlighted include biomedical imaging systems, high-throughput robotic screening platforms, X-ray diffractometers, mass spectrometers, nuclear magnetic resonance (NMR) spectrometers, DNA and protein sequencing instruments, biosensors, electron microscopes, light microscopes, and cell sorters. The language also makes clear that these examples are not exhaustive, so other high-end, specialized instruments may be considered if they fit the program goals and are justified by strong, multi-investigator scientific needs.
In terms of eligibility, the program is open to a broad set of organizations, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with 501(c)(3) status, nonprofit organizations without 501(c)(3) status (as described in the notice), and other entities as allowed under NIH policy and the specific eligibility clarifications in the announcement. The opportunity is categorized under the health funding activity area and is associated with CFDA numbers 93.351 and 93.859.
Administratively, the opportunity was created on February 8, 2021, with an original closing date of June 1, 2021. The title includes the note "S10 Clinical Trial Not Allowed," which signals that the mechanism is not intended to support clinical trials. In practical terms, applicants should frame the request around instrumentation that enables or enhances biomedical research broadly, rather than proposing a clinical trial as the primary activity supported by the award.
Overall, this HEI program is aimed at expanding access to expensive, cutting-edge research tools by funding a single major instrument purchase or upgrade that will be shared by multiple NIH-supported investigators, thereby improving institutional or regional research capacity and accelerating a range of NIH-relevant scientific projects.Apply for PAR 21 126
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "High-End Instrumentation (HEI) Grant Program (S10 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351, 93.859.
- This funding opportunity was created on Feb 08, 2021.
- Applicants must submit their applications by Jun 01, 2021. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- The number of recipients for this funding is limited to 25 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others (see text field entitled Additional Information on Eligibility for clarification).
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High-End Instrumentation (HEI) Grant Program (PAR-21-126) FAQs
What is the High-End Instrumentation (HEI) Grant Program (PAR-21-126)?
The High-End Instrumentation (HEI) Grant Program is a National Institutes of Health (NIH) discretionary grant opportunity under the U.S. Department of Health and Human Services. It supports the acquisition or upgrade of one major piece of expensive, specialized, commercially available research equipment, or an integrated instrumentation system, intended for shared use by multiple NIH-supported investigators.
What is the main purpose of this funding opportunity?
The main purpose is to strengthen biomedical and life-science research capabilities by expanding access to high-end instruments that are too costly for a single lab to purchase on its own. A key expectation is shared use: the proposed instrument should substantially enhance multiple NIH-supported projects and users, not primarily serve one investigator or one laboratory.
Who is this program designed to help?
This program is designed for groups or consortia of investigators who already hold NIH support and can demonstrate a strong, multi-investigator need for a single high-end instrument that will be shared among multiple projects and users.
Does the program fund one instrument or multiple instruments?
The program is designed to fund one major piece of equipment or one integrated instrumentation system (either as a new purchase or as an upgrade). The focus is on a single high-end instrument request that enables shared use across multiple NIH-supported investigators.
What is the award size for this program?
Awards range from a minimum of $600,001 to a maximum NIH award amount of $2,000,000.
Is there a maximum allowable purchase price for the instrument?
No maximum instrument price is stated. However, while the instrument can cost more than $2,000,000, the NIH award will not exceed the $2,000,000 cap. If the total instrument cost is higher, applicants may need to cover the difference through institutional funds, cost sharing, or other sources.
If the instrument costs more than $2,000,000, can the application still be competitive?
The opportunity description indicates the instrument itself may exceed $2,000,000, but the NIH award will not. That implies applications may still be possible when the total price is above the cap, as long as the request to NIH stays within the $2,000,000 maximum and a plan exists to cover remaining costs through other sources.
What kinds of instruments are supported?
The program supports high-end, specialized, commercially available biomedical and life-science research instruments and systems. Examples explicitly mentioned include biomedical imaging systems, high-throughput robotic screening platforms, X-ray diffractometers, mass spectrometers, nuclear magnetic resonance (NMR) spectrometers, DNA and protein sequencing instruments, biosensors, electron microscopes, light microscopes, and cell sorters.
Are the listed instrument examples the only allowable types?
No. The examples are described as not exhaustive. Other high-end, specialized instruments may be considered if they fit the program goals and are justified by strong, multi-investigator scientific needs.
Does the program support purchasing new equipment, upgrading existing equipment, or both?
Both. The program is intended to help groups of NIH-supported investigators acquire or upgrade one major piece of expensive, specialized research equipment, or an integrated system.
What does "shared use" mean in the context of this program?
Shared use is a central concept of the HEI program. The application is expected to be driven by a consortium or group of NIH-funded researchers and should show that the single high-end instrument will strengthen the research capabilities of multiple projects and multiple users, rather than primarily benefiting one lab.
What types of organizations are eligible to apply?
Eligibility is open to a broad range of organizations, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with 501(c)(3) status, nonprofit organizations without 501(c)(3) status (as described in the notice), and other entities as allowed under NIH policy and the specific eligibility clarifications in the announcement.
Is this opportunity limited to the health and biomedical research area?
Yes. The opportunity is categorized under the health funding activity area and is focused on supporting advanced biomedical and life-science research instrumentation.
What does "S10 Clinical Trial Not Allowed" mean?
The title note "S10 Clinical Trial Not Allowed" indicates the mechanism is not intended to support clinical trials. Applications should frame the request around instrumentation that enables or enhances biomedical research broadly, rather than proposing a clinical trial as the primary activity supported by the award.
How many awards does NIH expect to make?
The opportunity anticipates making around 25 awards, suggesting a competitive selection process.
What is the Funding Opportunity Number for this HEI program?
The Funding Opportunity Number is PAR-21-126.
Which federal department and agency sponsor this opportunity?
This is a National Institutes of Health (NIH) opportunity under the Department of Health and Human Services.
What are the associated CFDA numbers?
The opportunity is associated with CFDA numbers 93.351 and 93.859.
When was this funding opportunity created and what was the original closing date?
The opportunity was created on February 8, 2021, and had an original closing date of June 1, 2021.
What is the core benefit NIH is trying to achieve with this program?
The program aims to expand access to expensive, cutting-edge research tools by funding a single major instrument purchase or upgrade that will be shared by multiple NIH-supported investigators. The broader goal is to improve institutional or regional research capacity and accelerate a range of NIH-relevant scientific projects.
Does the program require that investigators already have NIH support?
Yes, the description states it is designed to help groups of investigators who already hold NIH support, and it emphasizes a consortium or group of NIH-funded researchers driving the application.
Can the requested instrument be part of an integrated instrumentation system?
Yes. The opportunity explicitly allows funding for one major piece of equipment or an integrated instrumentation system.
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